SQL Server 2019

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create table userBusinessArea (
    businessAreaID int not null,
    userID int not null,
    primary key (businessAreaID, userID)
);
insert into userBusinessArea
(businessAreaID, userID)
values
(21,368);
1 rows affected

-- fails
INSERT INTO [userBusinessArea]
           ([businessAreaID]
           ,[userID])
     VALUES
           (21, 368), 
           (21, 227419) ,
           (21, 99906), 
           (21, 140470)
Msg 2627 Level 14 State 1 Line 2
Violation of PRIMARY KEY constraint 'PK__userBusi__C65F5C72EC3F0844'. Cannot insert duplicate key in object 'dbo.userBusinessArea'. The duplicate key value is (21, 368).
Msg 3621 Level 0 State 0 Line 2
The statement has been terminated.

-- succeeds (no rows)
INSERT INTO [userBusinessArea]
           ([businessAreaID]
           ,[userID])
SELECT 
    businessAreaID,
    userID
FROM (
     VALUES
           (21, 368), 
           (21, 227419) ,
           (21, 99906), 
           (21, 140470)
) v (businessAreaID, userID)
WHERE v.userID NOT IN (368,227419,99906,140470);
-- succeeds (3 rows)
INSERT INTO [userBusinessArea]
           ([businessAreaID]
           ,[userID])
SELECT 
    businessAreaID,
    userID
FROM (
     VALUES
           (21, 368), 
           (21, 227419) ,
           (21, 99906), 
           (21, 140470)
) v (businessAreaID, userID)
WHERE NOT EXISTS (
    SELECT 1
    FROM userBusinessArea uba
    WHERE v.businessAreaID = uba.businessAreaID
      AND v.userID = uba.userID
);
3 rows affected